Доказательная Китайская фармакотерапия.

Доказательная Китайская фармакотерапия.

Сообщение Вадим Асадулин » Вс май 21, 2006 6:33 am

В отличие от топика "Доказательная Тибетская Медицина", я решил уточнить название топика по китайской фармакотерапии, т. к. у обывателя Китайская Медицина обычно ассоциируется с иглоукалыванием. В топике про Тибетскую Медицину я буду публиковать информацию по конкретным препаратам, которые есть у меня в наличии и с которыми я работаю много лет. Подобного опыта применения доступных китайских препаратов, за исключением, пожалуй, Bai Xiao Dan, у меня нет. Я набрал в поисковике PubMed 2 варианта словосочетаний: china medicine и china drug. Получил около 10000 ссылок! Я думаю, есть смысл собрать всю информацию по доступным препаратам из всех этномедицин. Публикую информацию, выбранную наугад. М. б. кто-нибудь займётся переводами?

Gastroprotective effect of a traditional Chinese herbal drug "Baishouwu" on experimental gastric lesions in rats.

Shan L, Liu RH, Shen YH, Zhang WD, Zhang C, Wu DZ, Min L, Su J, Xu XK.

J. Ethnopharmacol. 2006 Apr 6;
School of Pharmacy, Second Military Medical University, 325# Guo He Road, Shanghai 200433, PR China.

"Baishouwu" is an appellative name of dried root tubers from three Asclepiadaceae plants: Cynanchum auriculatum Royle ex Wight, Cynanchum bungei Decne and Cynoctonum wilfordii Maxim. In order to establish the pharmacological basis for the ethnomedicinal use of Baishouwu in gastric disorders, this study examined the effects of ethanol extracts and fractions from root tubers of Cynanchum auriculatum, Cynanchum bungei and Cynoctonum wilfordii on ethanol-, indomethacin-induced gastric lesions and histamine-induced gastric acid secretion in rats. Plant materials were collected from various areas of China. Oral administration of ethanol extract and chloroform fraction of Cynoctonum wilfordii collected from Changbai Cordillera at doses of 150 and 68mg/kg, respectively, significantly inhibited the development of ethanol- and indomethacin-induced gastric lesions and also caused significant decrease of gastric acid secretion after histamine-induced gastric lesion. Oral administrations of ethanol extract and chloroform fraction of Cynanchum auriculatum collected from Binhai at the doses of 300 and 69mg/kg, respectively, significantly inhibited ethanol- and indomethacin-induced gastric lesions. This study demonstrates the gastroprotective property of Baishouwu for the first time.
Вадим Асадулин
 
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Сообщение Вадим Асадулин » Пн окт 09, 2006 9:05 am

Кордицепс китайский. Cordiceps sinensis. Применяется в Китайской Традиционной Медицине. Вкус сладкий. Свойства тёплые. Тропность к меридианам Почек и Лёгких. Действие: тонизирует Лёгкие, питает Почки, повышает свёртываемость крови. Применяется при импотенции со сперматореей, при болях в пояснице и в конечностях; при длительном кашле с мокротой и кровохаркании, вследствие тяжёлой физической нагрузки, половых излишеств и злоупотреблении алкоголем, удушье; в период выздоровления; при повышенной потливости от небольшой физической нагрузки, при переохлаждении. Может применяться в пищу с куриным, утиным или свиным мясом по 5-10 граммов на приём. Противопоказан при наличии Поверхностного синдрома.

Американские исследователи установили, что одна из пищевых добавок, сделанная на основе китайского гриба кордисепса, увеличивает мышечную силу и повышает выносливость. Отчет о работе ученых будет представлен на апрельском съезде Американского общества физиологов (American Physiological Society).
По некоторым данным, напиток из экстракта таких грибов позволил китайским спортсменам поставить несколько рекордов в 1993 году. Сайт NewsWise.com подтверждает эти сведения результатами научных исследований.
В экспериментах приняли участие мужчины и женщины в возрасте от 40 до 70 лет. Одной группе давали биологически активную добавку CordyMax на основе кордицепса, а другой - "пустышку" плацебо. Через 12 недель исследователи сравнили у этих групп такие показатели как выносливость, мышечную силу и скорость некоторых биохимических процессов.
Выяснилось, что экстракт китайских грибов делает использование кислорода более эффективным, что позволяет переносить длительные физические нагрузки. Те, кто принимал добавку, стали быстрее проходить километровую дистанцию и похудели на несколько килограмм. Также медики отметили у них небольшое снижение артериального давления.

Кто знает другие Традиционные Китайские препараты, прошедшие доказательные исследования и применяемые китайскими спортсменами для повышения выносливости и силы?
Вадим Асадулин
 
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Сообщение Вадим Асадулин » Чт дек 07, 2006 8:03 am

Treatment of 60 Cases of Rheumatoid Arthritis by Self-formulated Wanbi Decoction.  
Objective: To observe the clinical effect of self-formulated prescription, Wanbi Decoction (WBD, decoction of Protracted Block-Syndrome), in treating rheumatoid Arthritis.  
Methods:
( l ) Referring to the diagnostic Standard for rheumatoid arthritis proposed by American Rheumatism Association, l987;
(2) 60 patients were diagnosed and treated with WBD (Radix Astragalus 30-60g, Radix Paeoniae lactiflora Alba 20g, Radix Angelica Sinensis l2g, Rhizoma Ligusticum Wallichii l2g, Rhizoma et Radix Notopterygium l2g, Radix Angelica Pubescens l2g, Ramulus Loranthi 20g, Cortex Eucommia l2g, Radix Gentiana Macrophylla l2g, Radix Stephania Tertrandra l2g, Poria l5g, Rhizoma Atractylodes Alba 12g, Pericarpium Citrus Reticulata l2g, Caulis Spatholobus 30g & Radix Salvia Miltiorrhizae l5g, Herba Epimedium l2g, Radix Glycyrrhiza l0g), one dose per day by boiled in water, Per Os' for 2 weeks as a therapeutic course.
The prescription would be modified depending the symptom or Syndrome: Site of disease on upper limbs, Ramulus Morus and Rhizoma Curcumae wenchowensis were added; on lower limbs, Fructus Chaenomeles and Radix Achyranthis Bidentatae added; for Syndrome of Heat dominant, Caulis Tripterygium Wilfordii, Rhizoma Rhemarrhena and Caulis Lonicerae added; for Kidney deficiency with Cold-dampness, Radix Rehmannia, Fructus Psoralae, Semen Cuscutae, Ramulus Cinnamomum and Radix Aconitum Carmichaeli Praeparata added; with prominent swelling joint, increase the dose of Poria and Rhizoma Atractylodes Alba, and Semen Coicis and Rhizoma Atractylodes added; with long course of disease and joint deformation, Flos Carthamus, Lumbricus, Scolopendra, etc. added; severe joint pain, Resin Boswellia carterii and Resin Commiphora Myrrha might be added. The effect on time of morning stiff number of pain or swelling joints, degree of arthralgia or swelling, function of affected joints, grip strength of hands, time for walking 20 meters, erythrocyte sedimentation rate, rheumatoid factor was observed;
(3) The effect was classified into 4 degrees: clinical cured: symptoms and signs disappeared with normal joint function, the accumulative total scores (scoring according to symptoms and signs) lowered to zero. Results of chief Physico-chemical examination restored to normal; markedly effective: symptoms and signs disappeared basically with improved joint function, the accumulative total scores lowered by 2/3 of that before treatment, Results of chief physico-chemical examination restored to normal basically; effective: symptoms and signs improved, the accumulative total scores lowered by l/3 of that before treatment, Results of chief physico-chemical examination improved; ineffective: no improvement was found in symptoms and signs, accumulative total scores unchanged or even increased.
Result: In the 60 patients, 7 were clinically cured, 25 markedly effective, 23 effective and 5 ineffective, the total effective rate being 90.l%.
Conclusion: WBD has effect in treating rheumatoid arthritis, by way of integral regulation, it could promote the restoration of body function, activate blood circulation to remove stasis, improve microcirculation and adjust immune function, so as to reach the aim of treating both the base and superficiality.
By Wang Jun,
TCM Hospital of Binzhou District, Shandong province 256600, China
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Вадим Асадулин
 
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Сообщение Вадим Асадулин » Чт июн 07, 2007 9:07 pm

Ann Pharmacother. 2001 Apr;35(4):501-4
Interaction between warfarin and danshen (Salvia miltiorrhiza).
Chan TY.
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories. Ссылка скрыта от незарегистрированных пользователей, пожалуйста зарегистрируйтесь или войдите!
OBJECTIVE: To discuss the potential for an adverse interaction between the Chinese herb danshen, the dry root and rhizome of Salvia miltiorrhiza Bge, and warfarin. DATA SOURCES: A MEDLINE search was performed (from January 1966 through October 2000) using the key words danshen and Salvia miltiorrhiza. All articles written in English or with an English extract were considered for review. STUDY SELECTION AND DATA EXTRACTION: All studies of antithrombotic effects of danshen or interaction between danshen and warfarin were evaluated. Previous case reports of an adverse interaction between danshen and warfarin were reviewed. DATA SYNTHESIS: Danshen is commonly used in mainland China for the treatment of atherosclerosis-related disorders such as cardiovascular and cerebrovascular diseases. Danshen can affect hemostasis in several ways, including inhibition of platelet aggregation, interference with the extrinsic blood coagulation, antithrombin III-like activity, and promotion of fibrinolytic activity. Single-dose and steady-state studies in rats indicated that danshen increased the absorption rate constants, AUCs, maximum concentrations, and elimination half-lives, but decreased the clearances and apparent volume of distribution of both R- and S-warfarin. Consequently, the anticoagulant response to warfarin was exaggerated. Three cases have previously been published reporting gross overanticoagulation and bleeding complications when patients receiving chronic warfarin therapy also took danshen. CONCLUSIONS: Because of both pharmacokinetic and pharmacodynamic interactions, danshen should be avoided in patients taking warfarin.
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Сообщение Вадим Асадулин » Пн июн 11, 2007 12:43 pm

WARFARIN AND CHINESE MEDICINE.
Alternatives to warfarin are in advanced stages of drug research. One of the central problems with use of warfarin is its limited dosage range for therapeutic benefit and safety and its apparent susceptibility to interactions. These issues are related to the nature of the warfarin molecule, being somewhat similar to several naturally occurring compounds, and its interaction with at least six vitamin-K dependent clotting factors. As an example of a potential alternative, the drug ximelagatran (brand name: Exanta) is metabolized to yield melagatran, which inhibits only thrombin. This may allow patients to take a single prescribed dosage without having to frequently monitor the INR and adjust dosage; in addition, it appears to have a low level of interactions. As of this writing, the drug is not approved in the U.S., but is being used for some limited applications in Europe (short-term therapy for leg surgeries). A potential role for Chinese blood-vitalizing herbs will still be present even if this (or other alternatives to warfarin) provides a safer anticoagulant therapy.
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Вадим Асадулин
 
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Сообщение Вадим Асадулин » Вс фев 03, 2008 8:00 pm

Guang Pu Xue Yu Guang Pu Fen Xi. 2006 Sep ;26 (9):1728-31 17112056
[Determination of 15 trace elements in antineoplastic traditional Chinese medicine by atomic absorption spectrometry]

Yan-Ming Liu , Hui Wang , Jin-Tu Han , Zhi-Ge Lou , Shi-Ping Yue

Five kinds of antineoplastic traditional Chinese medicines including fufangtianxian capsule, xiaoaiping tablet, zhiling capsule, shenlian capsule and shenlinglan capsule were digested with HNO3-HCl mixed acid. The fifteen trace elements including calcium, magnesium, potassium, sodium, iron, zinc, manganese, cobalt, nickel, chromium, silver, copper, strontium, cadmium and lead in the above-mentioned drugs were determined by atomic adsorption spectrometry. The effects of the kinds of mixed acid, the ratio of HNO3 to HCl in the mixed acid, the volume of digesting solution and the digesting time were also investigated in detail. The results obtained show that the concentrations of Ca, Mg, K, Na, Fe, Zn, Mn, Co and Ni in the five kinds of antineoplastic Chinese traditional medicines are higher than those of other elements.
[Pubmed] [Scholar] [EndNote] [BibTex]

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Вадим Асадулин
 
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Сообщение Вадим Асадулин » Пт фев 22, 2008 11:18 pm

Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 11.
Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia.
Shinno H, Inami Y, Inagaki T, Nakamura Y, Horiguchi J.
Department of Psychiatry, Shimane University Faculty of Medicine, 89-1 Enya, Izumo, Shimane 693-8501, Japan; Department of Neuropsychiatry, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
OBJECTIVE: Recently, traditional herbal medicines have been reported to be effective for behavioral and psychological symptoms of dementia (BPSD). This study aims to examine the efficacy of Yi-Gan San (YGS) in the improvement of BPSD and sleep disorders in patients with dementia. METHODS: Five patients (1 male and 4 female) with dementia in accordance with DSM-IV criteria were investigated. Participants were treated with YGS for 4 weeks. The Nursing Home version of Neuropsychiatric Inventory (NPI-NH) for the assessment of BPSD, the Mini-Mental State Examination (MMSE) for cognitive function, polysomnography for evaluation of sleep structure, and the Pittsburgh Sleep Quality Index for subjective sleep quality were carried out at baseline and at the end of treatment. RESULTS: All patients completed the trial. Significant improvements in the total NPI-NH score (34.0+/-6.5 to 12.8+/-6.6) as well as delusions, hallucinations, agitation/aggression, anxiety, and irritability/lability, whereas MMSE scores were unchanged. PSG revealed increases in total sleep time, sleep efficiency, stage 2 sleep, and decreases in the number of arousals and periodic limb movements. Subjective sleep quality was also improved. No adverse effects were observed. CONCLUSION: YGS was effective for BPSD and sleep disturbances, and well tolerated in patients with dementia. Further examinations using a double-blind placebo-controlled design are necessary.
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Prog Neuropsychopharmacol Biol Psychiatry. 2007 Dec 14.
Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: An open-label study.
Miyaoka T, Furuya M, Yasuda H, Hayashida M, Nishida A, Inagaki T, Horiguchi J.
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo, 693-8501, Japan.
BACKGROUND: Recent studies indicate that the traditional Japanese herbal medicine yi-gan san (YGS, yokukan-san in Japanese), a serotonin modulator, may be safe and useful in treating behavioral and psychological symptoms in dementia and borderline personality disorder patients. The authors examined the efficacy, tolerability, and safety of YGS in patients with tardive dyskinesia. METHODS: Twenty-two patients with schizophrenia who had neuroleptic-induced tardive dyskinesia were given 7.5 g/day of YGS for 12 weeks in an open-label study. RESULTS: Administration of YGS resulted in a statistically significant improvement in tardive dyskinesia and psychotic symptoms. CONCLUSIONS: YGS may be an effective and safe therapy to control tardive dyskinesia and psychosis in patients with schizophrenia, that should be further tested in double-blind, placebo-controlled trials.
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Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):150-4. Epub 2007 Aug 8.
Yi-gan san for the treatment of borderline personality disorder: An open-label study.
Miyaoka T, Furuya M, Yasuda H, Hayashia M, Inagaki T, Horiguchi J.
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo 693-8501, Japan.
BACKGROUND: Numerous medications have been tested on patients with borderline personality disorder (BPD). Although many of these medications have been demonstrated to be useful, no clear main treatment for BPD has emerged. Despite the efficacy of some of the medicines, acceptability and side effects have proven to be barriers to their use. Recent studies indicate that the traditional Chinese herbal medicine yi-gan san (YGS, yokukan-san in Japanese) may be safe and useful in treating behavioral and psychological symptoms in dementia patients. We aimed at evaluating both efficacy and safety of yi-gan san in patients with well-defined BPD. METHODS: Twenty female outpatients diagnosed with BPD according to DSM-IV criteria and the revised Diagnostic Interview for Borderlines completed a 12-week open-label study with yi-gan san at an average daily dosage of 6.4+/-1.9 g (2.5-7.5 g). Psychometric instruments to assess efficacy included the Brief Psychiatric Rating Scale (BPRS), Hamilton Rating Scales for Depression (HAM-D), Global Assessment of Functioning (GAF), Clinical Global Impression Scale (CGI), and Aggression Questionnaire (AQ). RESULTS: Most psychometric scale scores exhibited a highly significant improvement (total BPRS; BPRS somatic concern, anxiety, tension, depressive mood, hostility, suspiciousness, motor retardation, uncooperativeness, and excitement subscale; CGI; GAF; AQ) over time. CONCLUSIONS: In this open-label pilot study, patients treated with YGS showed statistically significant reduction on self-rated and clinician-rated scales. The present findings suggest that yi-gan san might be effective for the treatment of a number of BPD symptoms, including low mood, impulsivity, and aggression.
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Prog Neuropsychopharmacol Biol Psychiatry. 2007 Oct 1;31(7):1543-5. Epub 2007 Aug 3.
Successful treatment with Yi-Gan San for psychosis and sleep disturbance in a patient with dementia with Lewy bodies.
Shinno H, Utani E, Okazaki S, Kawamukai T, Yasuda H, Inagaki T, Inami Y, Horiguchi J.
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Evid Based Complement Alternat Med. 2006 Dec;3(4):441-5. Epub 2006 Oct 23.
The use of herbal medicine in Alzheimer's disease-a systematic review.
Dos Santos-Neto LL, de Vilhena Toledo MA, Medeiros-Souza P, de Souza GA.
The treatments of choice in Alzheimer's disease (AD) are cholinesterase inhibitors and NMDA-receptor antagonists, although doubts remain about the therapeutic effectiveness of these drugs. Herbal medicine products have been used in the treatment of Behavioral and Psychological Symptoms of Dementia (BPSD) but with various responses. The objective of this article was to review evidences from controlled studies in order to determine whether herbs can be useful in the treatment of cognitive disorders in the elderly. Randomized controlled studies assessing AD in individuals older than 65 years were identified through searches of MEDLINE, LILACS, Cochrane Library, dissertation Abstract (USA), ADEAR (Alzheimer's Disease Clinical Trials Database), National Research Register, Current Controlled trials, Centerwatch Trials Database and PsychINFO Journal Articles. The search combined the terms Alzheimer disease, dementia, cognition disorders, Herbal, Phytotherapy. The crossover results were evaluated by the Jadad's measurement scale. The systematic review identified two herbs and herbal formulations with therapeutic effects for the treatment of AD: Melissa officinalis, Salvia officinalis and Yi-Gan San and BDW (Ba Wei Di Huang Wan). Ginkgo biloba was identified in a meta-analysis study. All five herbs are useful for cognitive impairment of AD. M. officinalis and Yi-Gan San are also useful in agitation, for they have sedative effects. These herbs and formulations have demonstrated good therapeutic effectiveness but these results need to be compared with those of traditional drugs. Further large multicenter studies should be conducted in order to test the cost-effectiveness of these herbs for AD and the impact in the control of cognitive deterioration.
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J Clin Psychiatry. 2005 Dec;66(12):1612-3.
Effects of the traditional Chinese herbal medicine Yi-Gan San for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in patients with dementia with Lewy bodies.
Iwasaki K, Maruyama M, Tomita N, Furukawa K, Nemoto M, Fujiwara H, Seki T, Fujii M, Kodama M, Arai H.
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J Clin Psychiatry. 2005 Feb;66(2):248-52.
A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients.
Iwasaki K, Satoh-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N, Tanji H, Fujiwara H, Seki T, Fujii M, Arai H, Sasaki H.
Department of Geriatrics and Complementary Medicine, Graduate School of Medicine, Tohoku University, Sendai City, Japan.
OBJECTIVE: This randomized, observer-blind, controlled trial examined the efficacy and safety of the traditional Chinese herbal medicine Yi-Gan San (YGS, Yokukan-San in Japanese) in the improvement of behavioral and psychological symptoms of dementia (BPSD) and activities of daily living (ADL). METHOD: Fifty-two patients with mild-to-severe dementia (24 men and 28 women, mean +/- SD age = 80.3 +/- 9.0 years) according to DSM-IV criteria were investigated. Participants were randomly assigned to the YGS group (N = 27) or control (drug-free) group (N = 25) and treated for 4 weeks. The Neuropsychiatric Inventory (NPI) for the assessment of BPSD, the Mini-Mental State Examination (MMSE) for cognitive function, and the Barthel Index for ADL were administered at baseline and the end of the treatment. The frequency of extrapyramidal symptoms (EPS) and other adverse events was recorded. If patients showed insufficient response to treatment after 1 week, tiapride hydrochloride, a dopamine D(1) selective neuroleptic, was added to the regimen. Data were collected from January 2004 to March 2004. RESULTS: All participants in both groups completed the trial. In the control group, 11 patients required treatment with tiapride hydrochloride. Significant improvements in mean +/- SD NPI (from 37.9 +/- 16.1 to 19.5 +/- 15.6) and Barthel Index (from 56.4 +/- 34.2 to 62.9 +/- 35.2) scores were observed in the YGS group, but not in the control group. MMSE results were unchanged in both groups. EPS were not observed in either group, but dizziness and impaired postural sway were observed in 6 patients treated with tiapride hydrochloride. CONCLUSION: Yi-Gan San improves BPSD and ADL. Follow-up studies using a double-blinded, placebo-controlled design are recommended.
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Сообщение Вадим Асадулин » Вс апр 13, 2008 12:11 pm

Интересный ресурс Traditional Chinese Herbal Medicine с исследованиями эффективности при разной патологии в стандартах ЕВМ:
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Вадим Асадулин
 
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Сообщение Вадим Асадулин » Вс апр 13, 2008 12:29 pm

487 ссылок ресурса Cochrane на доказательные исследования препаратов Традиционной Китайской Медицины: Ссылка скрыта от незарегистрированных пользователей, пожалуйста зарегистрируйтесь или войдите!
Вадим Асадулин
 
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Сообщение Вадим Асадулин » Вс апр 13, 2008 6:41 pm

Traditional Chinese interventions for stable angina.
Zheng Jie, Li Jin, Liu Guanjian, Chen Xiaoyan, Wang Qin, Ni Juan, Wei Jiafu, Duan Xin, Zhou Likun
Background: Traditional Chinese medicines have been used by more and more physicians for its anti-angina properties. But their anti-angina properties and adverse effects should be systematically reviewed.
Objectives: To assess the effect (harms and benefits) of traditional Chinese medicines for stable angina. Specific comparisons will be made between traditional Chinese medicine and current standard treatment regimen.
Methods: We hand-searched about 60 kinds of Chinese traditional medicine journals, and also searched the Cochrane Heart Review Group trials register, the Cochrane Controlled Trials Register, MEDILINE (1995 to 2003), EMBASE (1995 TO 2003), CBM (Chinese biomedical database, 1995 to 2003), Chinese Cochrane Centre Controlled Trials Register (to 2003), and Cochrane Library (to 2003). We also searched databases of undergoing trials in Current Controlled Trials (Ссылка скрыта от незарегистрированных пользователей, пожалуйста зарегистрируйтесь или войдите!). Still we contacted manufacturers and researchers in this field.
Randomised and quasi-randomised controlled trials comparing traditional Chinese medicine with other anti-angina drugs, placebo or no intervention, and comparison among different doses or routes of administrations of traditional Chinese medicine, and any adverse effects are included in our review.
Two reviewers independently assessed trial quality and extracted data. Study authors were contacted for additional information. Results: Twenty-one trials involving 1772 people were included in out review. (1)Symptom relief: Six trials involving 562 people compared traditional Chinese medicine (TCM) with routine therapy. Compared with routine therapy, TCM can significantly relieve the angina symptom (total odds ratio 5.90, 95% confidence interval 3.29 to 10.57). (2)ECG improvement: It was documented in twelve trials involving 1147 people, showing that TCM improve the ECG measurement better than routine therapy (total odds ratio 2.89, 95% confidence interval 2.24 to 3.72). (3)We particularly assessed effectiveness of composite Dansheng droplet pills: As one of the most common used TCM, composite Dansheng droplet pills and its effects and adverse reactions were also reviewed. Five trials involving 575 people, comparing composite Dansheng droplet pills with routine therapy and other TCM, showed that it could relieve the angina symptom (odds ratio 5.52, 95% confidence interval 3.07 to 9.90). Seven trials showed that Composite Dansheng droplet pills had significantly less adverse reactions caused by vasodilatation (e.g. headache, flush) (odds ratio 0.03, 95% confidence interval 0.01 to 0.09). However, based on four trials involving 475 people, the slight gastrointestinal reactions were more common with Composite Dansheng droplet pills than other routine therapies (odds ratio 5.62, 95% confidence interval 1.24 to 25.38).
Conclusions: Traditional Chinese interventions appear to be more effective than routine therapies in both reliving the angina symptoms and improving ECG measurements of angina patients. As to the adverse reactions, TCM seems have much less headache and flush caused by vasodilatation.
Acknowledgements: We thank Dr. Theresa Moore, Dr. Katherine Wornell and Prof. Taixiang Wu, for advice in writing this protocol.
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Сообщение Вадим Асадулин » Вт окт 07, 2008 10:27 am

Zhong Xi Yi Jie He Xue Bao. 2008 Aug.
Factor analysis of traditional Chinese medicine syndromes in 815 patients with unstable angina.
Article in Chinese. Wang J, He QY, Li HX, Fang YT.
Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
OBJECTIVE: To explore the laws of traditional Chinese medicine (TCM) syndromes in unstable angina, and to establish the preliminary diagnostic criteria for TCM syndromes. METHODS: Multi-center prospective research on TCM syndromes in 815 cases of unstable angina was done with the nonlinear dimension reduction by factor analysis. RESULTS: There were five extracted factors in factor analysis: F1, F2, F3, F4 and F5. F1 was yin deficiency of heart and kidney, F2 was deficiency of both heart and spleen, F3 was intermingled phlegm and blood stasis, F4 was qi deficiency and blood stasis, and F5 was yang deficiency and coagulated cold. Qi deficiency and blood stasis (F4) syndrome accounted for the maximum proportion. The diagnostic criteria for TCM syndromes were preliminarily and respectively established. CONCLUSION: Qi deficiency and blood stasis is the key factor of pathogenesis. The factor analysis can help us classify traditional Chinese medicine syndromes and establish the preliminary diagnostic criteria.
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Сообщение Вадим Асадулин » Вс сен 27, 2009 2:43 pm

Stroke. 2009 Mar.
Danqi Piantang Jiaonang (DJ), a traditional Chinese medicine, in poststroke recovery.
Chen C, Venketasubramanian N, Gan RN, Lambert C, Picard D, Chan BP, Chan E, Bousser MG, Xuemin S.
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BACKGROUND AND PURPOSE: Stroke is a leading cause of death and disability worldwide. Despite improvements in acute stroke treatment, many patients only make a partial or poor recovery. Therefore, there is a need for treatments that would further improve outcome. Danqi Piantang Jiaonang (DJ; NeuroAid), a traditional Chinese medicine widely used in China to improve recovery after stroke, has been compared with another traditional Chinese medicine in 2 unpublished randomized clinical trials. The results of these studies were pooled and reanalyzed to assess efficacy and safety. METHODS: Six hundred five subjects were randomized in 2 randomized double-blinded, controlled trials to receive either DJ or Buchang Naoxintong Jiaonang. Subjects were treated for 1 month. Inclusion criteria were: (1) patients with recent (from 10 days to 6 months) ischemic stroke; (2) patients satisfying Western diagnostic standards for stroke and traditional Chinese medicine standards for diagnosis of apoplexy; and (3) Diagnostic Therapeutic Effects of Apoplexy score >/=10. RESULTS: The functional outcome, measured by the Comprehensive Function Score component of the Diagnostic Therapeutic Effects of Apoplexy scale, showed a statistically significant superiority of DJ over the control treatment group (relative risk, 2.4; 95% CI, 1.28 to 4.51; P=0.007). Tolerance was excellent in both groups. CONCLUSIONS: The pooled analysis of 2 unpublished trials of DJ, a traditional Chinese medicine currently approved in China to improve neurological recovery after stroke, shows good tolerability and superiority of DJ over another traditional Chinese medicine also approved for stroke. A large double-blind randomized clinical trial is required to further assess the safety and efficacy of DJ.
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Cerebrovasc Dis. 2008 Apr 16.
Erratum in: Cerebrovasc Dis. 2009.
Danqi Piantan Jiaonang does not modify hemostasis, hematology, and biochemistry in normal subjects and stroke patients.
Gan R, Lambert C, Lianting J, Chan ES, Venketasubramanian N, Chen C, Chan BP, Samama MM, Bousser MG.
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BACKGROUND AND OBJECTIVE: Previous studies on Danqi Piantan Jiaonang (DPJ, NeuroAid), a traditional Chinese medicine, in stroke patients showed promising results. Our aim was to determine the safety of DPJ in normal subjects and stroke patients through a series of studies assessing its immediate and long-term effects, alone and in combination with aspirin, on hematological, hemostatic, and biochemical parameters. METHODS: We conducted 3 studies from December 2004 to May 2006. Study 1 was a case series which recruited 32 healthy volunteers who were given 2 oral doses of 4 DPJ capsules (0.4 g/capsule) 6 h apart. Study 2 was a randomized controlled trial of 22 healthy volunteers who received either 1 oral dose of aspirin 300 mg alone or a combination of 1 dose of aspirin 300 mg and 2 doses of 4 DPJ capsules taken 6 h apart. For both studies 1 and 2, hemostatic parameters (prothrombin time, activated partial thromboplastin time, fibrinogen, platelet aggregation, D-dimer) were tested at baseline, and after 2 and 8 h. Study 3 was a case series which recruited 10 patients with recent ischemic stroke (within 7 days) who were given 4 DPJ capsules taken orally 3 times a day for 1 month. Blood tests for hemostatic, hematological (complete blood count), and biochemical parameters (glucose, creatinine, alanine aminotransferase, aspartate transaminase, C-reactive protein) were performed at baseline, and after 1 and 4 weeks. RESULTS: Apart from the expected changes in platelet aggregation in subjects taking aspirin, no significant differences were detected in hemostatic parameters at baseline, and 2 and 8 h after oral intake of DPJ alone or in combination with aspirin. Likewise, no significant differences were observed in hematological, hemostatic, and biochemical parameters at baseline, and after 1 and 4 weeks of oral intake of DPJ. CONCLUSION: DPJ does not significantly modify hematological, hemostatic, and biochemical parameters in normal subjects and stroke patients. (c) 2008 S. Karger AG, Basel.
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J. Tradit Chin Med. 2005 Sep.
A clinical study on the treatment of urinary infection with Zishen Tongli Jiaonang.
Zhang M, Zhang D, Xu Y, Duo X, Zhang W.
Gong An Hospital, Tianjin 300050, China.
OBJECTIVE: To observe the therapeutic effects of Zishen Tongli Jiaonang (capsules for nourishing the kidney and promoting urination) for treatment of urinary infection. METHOD: The treatment group with a control group were randomly set up. 120 patients in the control group were given antibiotics according to drug sensitive tests for orally taking or intravenous drip, while 136 patients in the treatment group were additionally given the capsules on the basis of the above-mentioned treatment. One course of treatment lasted 2 weeks. Statistical analysis on the therapeutic effects was conducted after a two-course treatment. The recurrence rates of the two groups were compared one year later. RESULTS: The total remission rates were respectively 96.3% in the treatment group and 81.7% in the control group (P<0.05). The recurrence rates one year later were respectively 4.4% in the treatment group and 30.0% in the control group (P<0.01). CONCLUSION: The capsules show good effects for urinary infection, especially in the long-term effect.
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Сообщение Вадим Асадулин » Пн сен 28, 2009 4:32 am

Вадим Асадулин
 
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Сообщение Вадим Асадулин » Пт май 07, 2010 1:22 am

Китайские ученые показали, что мышьяк лечит рак крови.
Ученые из Китая продемонстрировали, как мышьяк может лечить лейкемию, нацеливаясь и убивая определенные белки, которые поддерживают раковые клетки живыми.
«Наше исследование показало, как мышьяк непосредственно нацеливается на эти белки и убивает их», - сказал доктор Чанг Ксиаовеи (Zhang Xiaowei) (State Key Laboratory of Medical Genomics in Shanghai, China).
«В отличие от химиотерапии, побочные эффекты мышьяка (при лечении острой промиелоцитарной лейкемии) очень низкие. Нет никакой потери волос или супрессии костного мозга (функции). Нас интересует, может ли мышьяк использоваться для лечения других раковых новообразований», - сказал доктор Чанг.
Известный своей токсичностью, мышьяк считался в прошлом королем среди ядов, так как симптомы отравления мышьяком похожи на симптомы холеры, и часто не диагностировались.
Однако, в Китае, мышьяк в течение, по крайней мере, 2 000 лет использовался в традиционной китайской медицине.
В 1992, группа китайских докторов сообщила о применении мышьяка для лечения острой промиелоцитарной лейкемии (ОПЛ), у которой отмечались удивительно высокие нормы излечения - более чем 90 % - в Китае.
Однако, фактические эффекты мышьяка и его взаимодействие с раком, никогда не были понятны – пока доктор Жанг и коллеги не использовали современные технологии для изучения действия мышьяка.
В работе, опубликованной 9-ого апреля в «Science», доктор Жанг и коллеги сообщают, что мышьяк атакует определенные белки, которые поддерживают раковые клетки живыми.
«Наше исследование показывает, как могут использоваться западные технологии, чтобы узнать о тайнах китайской медицины», - сказал доктор Жанг.
Согласно статье, мышьяк способствует деградации онкогенного белка, который стимулирует рост клеток ОПЛ. Этот белок, альфа PML-RAR, является сложным белком, содержащим последовательности белка «цинковых пальцев» PML и рецептора альфа ретиноивой кислоты. Ученые обнаружили, что мышьяк связывается непосредственно с остатками цистеина в «цинковых пальцах». Закрепление мышьяка вызывает олигомеризацию PML, «которая увеличивает его взаимодействие с маленьким убихинон-подобным модифицирующим (SUMO) – коньюгирующим ферментом UBC9, приводящий к усилению SUMO-илирования и деградации», - сообщают исследователи.
Клинический результат применения мышьяка в лечении ОПЛ известен, с 5-летним выживанием без рецидива заболевания у более, чем у 90 % пациентов с ОПЛ в Китае, заключают ученые.
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Сообщение Вадим Асадулин » Чт дек 23, 2010 1:24 pm

Изображение
Book Description.
This comprehensive resource consists of evidence-based systematic reviews of herbs and supplements. Ninety-eight rigorously reviewed monographs provide impartial data to help make unbiased clinical decisions. Validated rating scales are used to evaluate the quality of available evidence. Each monograph has extensive information including, synonyms or common names; a clinical overview of each herb; dosing/toxicology information from adult to pediatric dosages; adverse effects/precautions/contraindications; interactions; mechanism of action; history; table with discussion and review of the evidence; and brands used in clinical trials and third party testing. * An evidence-based approach provides readers with credible information on the efficacy and safety of a therapy so they can make a decision with confidence. * Research summaries provide readers with an overview of what the research reveals concerning the efficacy, safety, indications, and contraindications of herbs and supplements. * Evidence tables consolidate human clinical trial data, statistical analyses, magnitude of benefit, and quality of studies, summarizing study results and relevance to aid in decision-making. * The grading scale used to rate each herb and supplement is based on the United States Preventive Services Task Force (USPSTF), an independent panel of experts in primary care and prevention that systematically reviews the evidence of herb and supplement effectiveness and develops recommendations for clinical preventiveservices. This grading scale is very comprehensive.
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Сообщение Вадим Асадулин » Вс янв 16, 2011 5:50 am

Пришел ответ из магазина, что книги нет в наличии.
Пошел искать в других местах.
Нашел!
This is a very well referenced source providing detailed evidence-based systematic reviews for almost 100 herbs and supplements. It is particularly valuable for those clinicians who are using or who wish to use herbal medicine in their everyday practice and for doctors and patients who wish to know more about the efficacy and tolerability of herbal medicines. The volume confirms that although a few complementary treatments have been assessed in well-designed clinical trials, high quality information relating to effectiveness, dosage, mechanism of action and safety is limited or controversial for most therapies tested. As a result for almost all the products listed it is not possible to guarantee strength, purity or safety of products even though some have been shown to have clinical benefit.
More than 100 health professionals have contributed to the volume, mostly physicians and pharmacists but also nurses, microbiologists, educationalists, herbalists and other alternative practitioners and over 40 contributors make up the Editorial Board. The text is arranged alphabetically starting with Acidophilus and finishing with Yohimbe Bark. The layout is highly structured and easy to use as a reference source. The main headings are synonyms for the substance, clinical ‘bottom line’, grades of scientific evidence, summary table, dose and standardization of formulation, adverse effects, interactions and use in pregnancy. The grades of scientific evidence range from A to F with levels below B representing no evidence or evidence against the clinical effectiveness of the product. Grade A implies that there are more than 2 studies of reasonable design supporting the use of the substance and Grade B that there are one or two clinical trials. Overall Grade A evidence is rarely very good and the studies do not compare with the outcome trials undertaken within conventional medicine in terms of design, statistical power and analysis. Based on A and B grades there are a few surprises. I am sure that those physicians managing dementia and heart disease would be surprised that Ginkgo biloba and Ginseng are useful for enhancing memory and that Hawthorne gets an A Grade for the treatment of congestive heart failure. The latter benefit appears to be for Grades 1 and 2 New York Heart Association Classification, which is notoriously difficult to define accurately. Hepatologists might also like to know that Milk Thistle improves liver function tests in patients with chronic liver disease and urologists might be interested that Pygeum Africanum and Saw Palmetto might improve symptoms and reduce the size of the gland in patients with benign prostatic hypertrophy.
Otherwise most of the findings are as expected. Ephedra remains a very toxic substance with no clinical benefit and adverse effects and addiction potential similar to amphetamines and cocaine. Several dietary agents appear to lower the serum cholesterol – barley, soya, almonds, yeasts, garlic and fish oils and some evidence exists for feverfew in migraine prophylaxis and for St. John's Wort in depression. A number of agents are confirmed as having some analgesic or anti-inflammatory activity – Boswellia Serrata, Devil's Claw, Glucosamine, hypoglycaemic effects – Bitter Melon, Gymnema Sylvestre, and others appear useful for sleep disturbance – Valerian Officinalis, Melatonin. Cranberry juice and echinacea may be useful for urinary and upper respiratory infections.
The two final appendices, A and B, relate to drug interactions and conditions tables. In Appendix A a list of possible pharmacodynamic and pharmacokinetic interactions are listed. Unfortunately, reporting is generally low or goes undetected and the interactions are mostly based on additive effects of similar acting drugs, expert opinion and anecdote rather than clinical studies. The best evidence available relates to St. John's Wort, its interactions with antidepressant drugs and its effect as an enzyme inducer/inhibitor. Appendix B deals with the different medical conditions for which herbs and supplements have been used. These are also arranged alphabetically and identify treatments for which Grades A-D evidence is available. This section is likely to be consulted even more than the main alphabetical section as a rapid treatment reference.
In conclusion, this volume represents a most reliable source of up-to-date and balanced information on herbal medicine and the use of supplements. It provides an extremely useful systematic and easy to read resource for all drug prescribers with evidence-based reviews to identify the small amount of wheat from the large quantity of chaff in this area of alternative medicine.
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Во, вообще задаром:
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Нашел ещё книгу! Тоже хочу!
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Большой объем для скачивания! Почти 800 страниц!
Нашел сайт.
Natural Standard was founded by healthcare providers and researchers to provide high-quality, evidence-based information about complementary and alternative therapies. Grades reflect the level of available scientific data for or against the use of each therapy for a specific medical condition:
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Сообщение Вадим Асадулин » Вс авг 07, 2011 5:15 pm

J Ethnopharmacol. 2011 Jul 5.
A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.
Jeon S, Bose S, Hur J, Jun K, Kim YK, Cho KS, Koo BS.
Source.
Dongguk University Research Institute of Biotechnology, 26, 3-GA, Pil-dong, Chung-gu, Seoul 100-715, Republic of Korea.
Abstract.
ETHNOPHARMACOLOGICAL RELEVANCE:
SuHeXiang Wan (SHXW), a Chinese traditional medicine has been used orally for the treatment of seizures, infantile convulsion, stroke and so forth. Previously, we reported the effects of modified SHXW essential oil mixture of the fragrance containing herbs on the sedative effect, anticonvulsant property and antioxidative activity after fragrance inhalation.
MATERIALS AND METHODS:
This study was undertaken to evaluate beneficial effects of a modified recipe of SHXW (termed as KSOP1009) consisting of a ethanol extract of 8 herbs including resin of Liquidambar orientalis Miller, seed of Myristica fragrans Houtt., rhizome of Cnidium officinale Makino, lumber of Santalum album L., fructus of Piper longum L., flower buds of Eugenia caryophyllata Merrill et Perry, pollen of Typha orientalis Presl., and root of Salvia miltiorrhiza Bunge in the neurodegenerative diseases such as Alzheimer's disease (AD). The transgenic mice of AD, Tg-APPswe/PS1dE9, were fed KSOP1009 or as a positive control, donepezil for 3 months from 4.5 months of age. Behavioral, immunological and ELISA analyses were used to assess memory impairment, Aβ accumulation and plaque deposition in the brain. Other in vitro works were performed to examine whether KSOP1009 inhibits the Aβ(1-42)-induced neurotoxicity in human neuroblastoma cell line, SH-SY5Y cells.
RESULTS:
Intake of KSOP1009 improved the Aβ-induced memory impairment and suppressed Aβ levels and plaque deposition in the brain of Tg-APPswe/PS1dE9 mice as much as that of donepezil treatment. KSOP1009 prevented the down-regulation of phospho-CREB and increased AKT phosphorylation in the AD-like brains. Moreover, KSOP1009 suppresses Aβ-induced apoptosis and ROS production in SH-SY5Y cells.
CONCLUSION:
The present study suggests that KSOP1009 may develop as a therapeutic drug for treatment of AD patients.
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Сообщение Вадим Асадулин » Пн окт 17, 2011 3:00 am

Вадим Асадулин
 
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Сообщение Вадим Асадулин » Вт окт 25, 2011 9:32 pm

О лечении рака мочевого пузыря препаратом Китайской Традиционной Медицины.
Aqueous Extract of Shi-Liu-Wei-Liu-Qi-Yin Induces G2/M Phase Arrest and Apoptosis in Human Bladder Carcinoma Cells via Fas and Mitochondrial Pathway.
Прошу умельцев перевести в другой формат, удобный для цитирования и перевода.
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Evid Based Complement Alternat Med. 2009 May 25. [Epub ahead of print]
Aqueous Extract of Shi-Liu-Wei-Liu-Qi-Yin Induces G2/M Phase Arrest and Apoptosis in Human Bladder Carcinoma Cells via Fas and Mitochondrial Pathway.
Ou TT, Wang CJ, Hung GU, Wu CH, Lee HJ.
Source
Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Road, Taichung 402, Taiwan. Ссылка скрыта от незарегистрированных пользователей, пожалуйста зарегистрируйтесь или войдите!.
Abstract
Shi-Liu-Wei-Liu-Qi-Yin (SLWLQY) was traditionally used to treat cancers. However, scientific evidence of the anticancer effects still remains undefined. In this study, we aimed to clarify the possible mechanisms of SLWLQY in treating cancer. We evaluated the effects of SLWLQY on apoptosis-related experiments inducing in TSGH-8301 cells by (i) 3-(4,5-dimethylthiazol-zyl)-2,5-diphenylterazolium bromide (MTT) for cytotoxicity; (ii) cell-cycle analysis and (iii) western blot analysis of the G2/M-phase and apoptosis regulatory proteins. Human bladder carcinoma TSGH-8301 cells were transplanted into BALB/c nude mice as a tumor model for evaluating the antitumor effect of SLWLQY. Treatment of SLWLQY resulted in the G2/M phase arrest and apoptotic death in a dose-dependent manner, accompanied by a decrease in cyclin-dependent kinases (cdc2) and cyclins (cyclin B1). SLWLQY stimulated increases in the protein expression of Fas and FasL, and induced the cleavage of caspase-3, caspase-9 and caspase-8. The ratio of Bax/Bcl(2) was increased by SLWLQY treatment. SLWLQY markedly reduced tumor size in TSGH-8301 cells-xenografted tumor tissues. In the tissue specimen, SLWLQY up-regulated the expression of Fas, FasL and Bax proteins, and down-regulated Bcl(2) as well as in in vitro assay. Our results showed that SLWLQY reduced tumor growth, caused cell-cycle arrest and apoptosis in TSGH-8301 cells via the Fas and mitochondrial pathway.
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Re: Доказательная Китайская фармакотерапия.

Сообщение Вадим Асадулин » Ср янв 02, 2013 2:38 pm

Neuropharmacology. 2013 Feb;65:1-11. doi: 10.1016/j.neuropharm.2012.09.001. Epub 2012 Sep 10.
Alpha-asarone from Acorus gramineus alleviates epilepsy by modulating A-Type GABA receptors.
Huang C, Li WG, Zhang XB, Wang L, Xu TL, Wu D, Li Y.
Source
Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China; Neuroscience Division, Department of Biochemistry and Molecular Cell Biology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Abstract.
Alpha (α)-asarone is a major effective compound isolated from the Chinese medicinal herb Acorus gramineus, which is widely used in clinical practice as an antiepileptic drug; however, its mechanism of action remains unclear. In this study, we have characterized the action of α-asarone on the excitability of rat hippocampal neurons in culture and on the epileptic activity induced by pentylenetetrazole or kainate injection in vivo. Under cell-attached configuration, the firing rate of spontaneous spiking was inhibited by application of α-asarone, which was maintained in the Mg(2+)-free solution. Under whole-cell configuration, α-asarone induced inward currents in a concentration-dependent manner with an EC(50) of 248 ± 33 μM, which was inhibited by a GABA(A) receptor blocker picotoxin and a competitive GABA(A) receptor antagonist bicuculline but not a specific glycine receptor inhibitor strychnine. Measurement of tonic GABA currents and miniature spontaneous inhibitory postsynaptic currents indicated that α-asarone enhanced tonic GABAergic inhibition while left phasic GABAergic inhibition unaffected. In both pentylenetetrazole and kainate seizure models, α-asarone suppressed epileptic activity of mice by prolonging the latency to clonic and tonic seizures and reducing the mortality as well as the susceptibility to seizure in vivo presumably dependent on the activation of GABA(A) receptors. In summary, our results suggest that α-asarone inhibits the activity of hippocampal neurons and produces antiepileptic effect in central nervous system through enhancing tonic GABAergic inhibition.
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Вадим Асадулин
 
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Re: Доказательная Китайская фармакотерапия.

Сообщение IngvaR » Вт окт 01, 2013 3:29 pm

Ссылка скрыта от незарегистрированных пользователей. Пожалуйста, зарегистрируйтесь на форуме! Сочетанное применение традиционной китайской и западной медицины может привести к созданию новых схем противоракового лечения
Буду признателен за ответ.
Игорь Коробов
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IngvaR
 
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Re: Доказательная Китайская фармакотерапия.

Сообщение Вадим Асадулин » Чт окт 03, 2013 2:11 pm

IngvaR писал(а):Ссылка скрыта от незарегистрированных пользователей. Пожалуйста, зарегистрируйтесь на форуме! Сочетанное применение традиционной китайской и западной медицины может привести к созданию новых схем противоракового лечения

Ни чего конкретного...
Посмотрите выше, как нужно подавать информацию.
Вадим Асадулин
 
Сообщения: 1266
Зарегистрирован: Чт янв 20, 2005 5:42 pm
Откуда: Иркутск

Re: Доказательная Китайская фармакотерапия.

Сообщение IngvaR » Чт окт 03, 2013 8:00 pm

Вадим Асадулин писал(а):
IngvaR писал(а):Ссылка скрыта от незарегистрированных пользователей. Пожалуйста, зарегистрируйтесь на форуме! Сочетанное применение традиционной китайской и западной медицины может привести к созданию новых схем противоракового лечения

Ни чего конкретного...
Посмотрите выше, как нужно подавать информацию.

Вопрос не в том, как подавать информацию... вопрос в том, что ее очень мало и то, что попадается и в каком формате - выкладываю. По крайней мере - это официальный источник МОЗ Украины и на него можно ссылаться в некоторых случаях.
А по поводу конкретных находок (опубликованных выше) - вопросов нет: все подано хорошо.
Буду признателен за ответ.
Игорь Коробов
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IngvaR
 
Сообщения: 214
Зарегистрирован: Вт окт 26, 2004 12:46 pm
Откуда: Чернигов, Украина

Re: Доказательная Китайская фармакотерапия.

Сообщение Вадим Асадулин » Пт окт 04, 2013 5:03 am

IngvaR писал(а):Вопрос не в том, как подавать информацию... вопрос в том, что ее очень мало и то, что попадается и в каком формате - выкладываю. По крайней мере - это официальный источник МОЗ Украины и на него можно ссылаться в некоторых случаях.

Если лень, это - одно, если не умеете искать - другое.
Вот, пожалуйста, одна из статей про это лекарство, кстати, совсем свежая:
Oncol Rep. 2013 Jul 3. doi: 10.3892/or.2013.2586. [Epub ahead of print].
Antitumour effects of Yangzheng Xiaoji in human osteosarcoma: The pivotal role of focal adhesion kinase signalling.
Jiang WG, Ye L, Ji K, Ruge F, Wu Y, Gao Y, Ji J, Mason MD.
Source.
Cardiff University-Peking University School of Oncology Joint Institute, Cardiff CF14 4XN, UK.
Abstract.
The present study examined, in vitro and in vivo, the potential antitumour effects of Yangzheng Xiaoji (YZXJ), a traditional Chinese medical formula used in cancer treatment, on osteosarcoma, a tumour type recently found to be sensitive to YZXJ. The human osteosarcoma cell line MG63 was used in cell-matrix adhesion and cell growth assays. The same cell line was used in an in vivo tumour model by establishing subcutaneous osteosarcoma xenografts. Oral and intraperitoneal routes were used to deliver the YZXJ extract. The effect of YZXJ on the activation of focal adhesion kinase (FAK) and paxillin was evaluated by immunofluorescence methods. It was found that YZXJ exhibited a significant inhibitory effect on cell-matrix adhesion as demonstrated by a cell-based assay and electric cell-substrate impedance sensing (ECIS) analysis. The effect was observed together with a reduction in phospho-FAK and phospho-paxillin in the cells when treated with YZXJ. In the in vivo tumour model, YZXJ was found to significantly inhibit the growth of osteosarcoma with a sustained effect observed when YZXJ was delivered intraperitoneally. YZXJ sensitized cells to the effect of FAK inhibitor in vitro and in vivo. It is concluded that Yangzheng Xiaoji plays a significant role in cell-matrix adhesion and tumour growth, likely by inhibiting the activation of the FAK pathway. The therapeutic role of Yangzheng Xiaoji in osteosarcoma warrants further investigation.
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Есть ещё две, можете потренироваться!
Теперь, Ваша, очередь блеснуть составом на латыни! М. б. буду кому назначать!
Вооот! Еще сссылочка!
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Вадим Асадулин
 
Сообщения: 1266
Зарегистрирован: Чт янв 20, 2005 5:42 pm
Откуда: Иркутск



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